28 Multiple myeloma causes only osteolytic lesions.
Interestingly, A3V and T9I have protective effects on the development of multiple myeloma but cause severe clinical phenotypes when combined with R278H [157].
Trish Chelsen, whose husband, Roy, was a New York City firefighter, said she believed his death in January of multiple myeloma was caused by the chemicals at ground zero.
"When you start having hypocalcaemia, which is elevated calcium and protein levels, it's stage three," she said one afternoon, describing her brother's cancer, multiple myeloma, which causes the plasma cells in bone marrow to multiply uncontrollably, forming bone tumors.
Induction of osteolytic bone lesions in multiple myeloma is caused by an uncoupling of osteoclastic bone resorption and osteoblastic bone formation.
Multiple myeloma can cause spine changes on X-ray that look like osteoporotic vertebral fractures.
Multiple myeloma is caused by expansion of malignant plasma cells in the bone marrow (BM) and remains largely incurable with the current treatment options [ 1].
For example, multiple myeloma may cause renal damage due to amyloidosis, glomerular light/heavy chain deposition disease or cast nephropathy, as well as musculoskeletal pain due to local tumor growth.
It should be noted that the underlying diseases could have affected the DIPN incidence; for instance, multiple myeloma itself can cause PN.
Other differentials to consider include malignant processes such as ocular infiltration secondary to multiple myeloma or infective causes such as nodular anterior scleritis, chlamydia, herpetic infection, papilloma, tuberculosis and migratory phlyctenulosis [ 16].
