Notch-RBP-J signaling has been shown to control development and differentiation of multiple myeloid lineages including granulocyte/monocyte progenitors, dendritic cells, and osteoclasts (Klinakis et al., 2011; Lewis et al., 2011; Zhao et al., 2012).
Delhommeau and colleages then sequenced TET2 in patient tumor samples, becoming the first group to identify TET2 mutations in multiple myeloid neoplasms, including MDS (19%), MPNs (12%14%%), and sAML (24%).
It is implicated in multiple myeloid malignancies such as MDS and AML, but also in lymphoid malignancies and in fibrosarcomas [49].
While multiple myeloid lineages such as macrophage (M-CFCs), granulocyte (G-CFCs), and pan-myeloid CFCs (CFU-Mix) were observed from WT hESCs, we only observed mononuclear cells from GATA2 −/− hESCs, which displayed macrophage morphology under a microscope (Fig. 3e).
Analysis of multiple myeloid leukemia cell lines indicated robust expression of DDR1 on K562 cells (Fig. S1), therefore, this cell line was chosen to further investigate DDR1's role in myeloid leukemia.
This generally is sufficient to gate on the most relevant AML population with myeloid characteristics, including "immature"- and "mature -like phenotypes.
We recently described two new mouse models of systemic metastatic cancer in the inbred VM mouse strain that express multiple myeloid/macrophages characteristics to include phagocytosis, morphological appearance, and gene and lipid expression [ 14, 28, 185].
PCA was used to concurrently analyze multiple bacterial characteristics.
Note: multiple radiographic characteristics per patient are possible.
You can now use the word "and" to search for news that shares multiple characteristics.
