Sentence examples for multiple mutations within from inspiring English sources

While recombination can bring together multiple mutations within an organism, evolution in asexual populations depends on the sequential accumulation of mutations within a lineage.

A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci.

Indeed, multiple mutations within residues 636 642 of NEDD1 caused a significant reduction in binding to γ-tubulin both in vivo and in vitro.

Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations.

In principle, for a completely unannotated genome, one could predict open reading frames (ORFs) and detect clustering of multiple mutations within individual ORFs just as effectively as with annotated gene regions.

However, since oncogenesis is thought to occur following multiple mutations within a single cell, we proceeded to determine whether Casp9DN expression alone or in combination with other proven oncogenic models would promote oncogenesis.

Multiple mutations occurring within the same cell cycle and in rapid succession, typically within seconds to minutes [13].

In contrast, all of the felid UGT1A6 exon 1 sequences (Fig. S2) showed multiple mutations located within the coding region that either alter the reading frame, or directly result in premature stop codons.

One would need to model datasets in which multiple mutations occurred within the same gene along with the complex and realistic LD relationships for markers around each mutation.

We assessed the effect of multiple-mutations within one IgE-binding area on allergenicity of Der f 2. The triple-mutant of Der f 2, P34/95/99A, exhibited the most significant reduction of allergenicity and circular dichroism analysis showed that the global structure of Der f 2 was maintained in P34/95/99A.

Such a library would correctly identify more sequence variants than a traditional tiling library with variation at the single position where multiple mutations occur frequently within single probes and those mutations reflect a limited set of possible variants.