Sentence examples for multiple mutations to from inspiring English sources

It takes multiple mutations to transform one from a normal cell into a cancerous one.

In all cases, the response of multiple mutations to DEX was similar to single mutations within GLS1, GLS3, and GLS4 (Fig. 2B).

There is simply insufficient time for multiple mutations to occur and accumulate in a somatic cell with a limited life span (e.g., skin, 30 days; gut, 3 days).

The removal of the primer length limitation allows adjacent multiple mutations to be made in a single step with a pair of mutagenesis primers without any limitation.

However, in a number of recent studies, a prevalence of antagonistic epistasis (the tendency of multiple mutations to have a mitigating rather than reinforcing effect) has been observed.

To estimate the number of shared polymorphisms and shared derived mutations expected due to multiple mutations to the same site, we generated simulated 10,000 replicates of the observed number of derived mutations (both shared and private) at each locus.

The αB crystallin mutant αAβ8, which contains multiple mutations at residues corresponding to the 131LTITSSLS138 sequence increased microtubule assembly, completely inhibited microtubule disassembly, and decreased tubulin aggregation.

One way around these limitations is to examine and analyze gene expression from many individual genotypes that each contains multiple mutations and to study the covariance in phenotypes and multiple gene expression levels to hypothesize which of the gene expression changes might cause phenotypic deviations [ 38- 41].

Most single mutations did not affect the critical shape of the molecule, and multiple mutations tended to compensate for those that did.

Among the eight cases without TP53 or PIK3CA mutations, three demonstrated multiple mutations (two to six mutations per case).

Immune protection against multiple pathogen epitopes may prevent pathogens from generating the multiple mutations required to escape immune recognition [ 7].