Sentence examples for multiple mutations of from inspiring English sources

Multiple mutations of zinc finger (ZNF) genes were detected in the metastasis samples, and mutated genes that are involved in apoptosis and transcription regulations were enriched in metastases (Additional file 1: Table S10B).

That excess is likely caused by to the overactivation of a gene called hyaluronan synthase 2. Dogs that carry multiple mutations of the gene seem predisposed to periodic fever, Ms. Olsson and her colleagues reported.

LRRK2 is better studied in neurons, because multiple mutations of LRRK2 cause familial Parkinson's disease (PD) (Zimprich et al., 2004; Paisan-Ruiz et al., 2004).

To date such approaches have furnished novel activities through multiple mutations of residues involved in recognition; in no instance has a key catalytic residue been altered while activity is retained.

Single and multiple mutations of IN at residues T66, S153, or M154 confer degrees of resistance to several inhibitors that prevent the enzyme from performing its normal strand transfer activity.

Our data indicate that single or multiple mutations of KRAS, BRAF, or PIK3CA unfavorably affect clinical outcome to cetuximab- or panitumumab-based therapies; however, the possibility that these molecular alterations could be negative prognostic biomarkers independently from targeted therapies should be taken into account.

Another possible explanation for the lack of correlation between the embB gene alterations and EMB resistance may relate to a cumulative effect of multiple mutations on the development of EMB resistance.

We apply this procedure to characterize the effect of multiple mutations on the folding mechanism of protein S6.

In all cases, the response of multiple mutations to DEX was similar to single mutations within GLS1, GLS3, and GLS4 (Fig. 2B).

14, 37 Unlike the first-generation NNRTIs, etravirine requires multiple mutations for the development of resistance (Table 3).

APEX array technology facilitates the simultaneous analysis of multiple mutations through hybridization of fragmented template DNA to specifically designed primers, followed by single nucleotide extension at the site of each putative mutation [8], [9].