Our results reveal that one or more of these genes is mutated in around 35% of melanomas with some tumors exhibiting multiple mutations in these genes.
The induction of a mutator phenotype has been hypothesized to cause the accumulation of multiple mutations in the development of cancer.
It has been postulated that the strain that caused the influenza epidemic of 1918 19 derived all eight RNA segments from an avian virus and that this virus then underwent multiple mutations in the process of adapting to mammalian cells.
The CRISPR/Cas9 system provides a potential tool to introduce multiple mutations in a genome.
On the other hand, multiple mutations in the second helix result in a considerable increase in the refolding rate without any significant effect on the unfolding rate.
Sequence of the 10 mutant plasmids indicated that each plasmid contained single or multiple mutations in the rep gene or the flanking regions.
Current worldwide initiatives are expected to result in multiple mutations in every mouse gene in the first 10 years of the 21st century.
Since cDNAs are read intact, the system distinguishes between RNAs that reflect a single mutation vs. multiple mutations in a gene.
Because the asthma-prone mice had multiple mutations in both genes, the researchers couldn't determine whether one, the other, or both cause asthma.
Due to multiple mutations in the O-antigen gene cluster, Y. pestis fails to produce O-antigen, a structural component of lipopolysaccharide of Gram-negative bacteria (Prior et al., 2001).
Multiple mutations in the EGFR gene are a major cause for the failure of Erlotinib and Gefitinib in the treatment of patients harboring non-small-cell lung cancer (NSCLC) who initially responded to this therapy.
