Sentence examples for multiple mutational perturbations from inspiring English sources
These simulation results are discussed in the light of important themes of investigation, such as the relationship between the complexity of regulatory networks and the combinatorial effects of multiple mutational perturbations, as well as evolutionarily correlated responses.
We have followed a model-based design approach to obtain a minimal genetic unit with multiple functionalities and displaying certain homeostasis to both environmental and mutational perturbations, since external fluctuations or variations in kinetic parameters are compensated due to QS.
To further analyze combinational rare mutation genes in the pathway level mRNA expression, we iteratively combine mutated genes belonging to the pathway so that multiple mutational events on multiple genes can be considered into one mutational event.
In some passerine bird species, differing mutations that are not clearly related suggest the likelihood of multiple mutational events.
HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.
We wished to establish whether this high prevalence is due to a genetic founder effect or to multiple mutational events.
These structures can be relatively independently functioning modules, and then the RNA molecule is in its entirety (fitness) more robust to environmental and mutational perturbations than if the parts are nonmodular.
On these grounds, epistasis is manifested as non-linear correspondences between mutational perturbations in the regulatory properties of the networks and their spatio-temporal expression trajectories.
In summary, the broad research agenda that has been devoted to studying the phenotypic and fitness effects of mutational perturbations has convincingly demostrated that epistasis is a counter-intuitive and pervasive phenomenon in multidimensional GPMs.
A series of computer experiments were performed in order to explore epistatic interactions among a wide spectrum of simulated mutational perturbations in ensembles of regulatory network models relevant for early Drosophila embryogenesis.
The inference is that low Hsp90 levels increase sensitivity to mutational perturbations.
