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In addition to the ability to use a collection of trees and sample multiple mutational histories, our mutational mapping method also possessed advantages over the PAML maximum likelihood software [ 68, 69].
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To further analyze combinational rare mutation genes in the pathway level mRNA expression, we iteratively combine mutated genes belonging to the pathway so that multiple mutational events on multiple genes can be considered into one mutational event.
In some passerine bird species, differing mutations that are not clearly related suggest the likelihood of multiple mutational events.
HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.
We wished to establish whether this high prevalence is due to a genetic founder effect or to multiple mutational events.
Each deme would be expected to have somewhat different mutational histories and, as they are living in a variety of different ecological settings, to undergo different changes through natural selection and through genetic drift.
Shortly thereafter, several groups identified FMR1 deletions in FXS patients, suggesting that multiple mutational mechanisms could give rise to the disorder [2], [3], [4], [5].
The nature of the Kelch domain and SAS1 sequence has been characterized by multiple mutational studies involving careful deletion or amino-acid substitution analysis [10] [13].
Microsatellites have many mutational biases and are known to lead to multiple mutational events (Drake 2007; Schrider et al. 2011) and to mutational nonindependence (Amos 2010a).
Uncertainty in the mutational mapping process was accounted for by simulating, and averaging over, 10 mutational histories for each of the 1000 posterior phylogeny samples.
Stochastic mutational mapping [ 39, 40, 95] was used to infer mutational histories (maps) using posterior phylogeny samples taken from MrBayes runs.
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