Sentence examples for multiple mutational exposures from inspiring English sources

Often tumors show overlays of multiple mutational exposures and processes, which can be deconvolved by approaches based on non-negative matrix factorization (NMF) or software that uses related methods [ 16, 18, 19].

In most tumors, somatic mutation catalogs comprise the superimposed results of several mutational exposures and processes.

To further analyze combinational rare mutation genes in the pathway level mRNA expression, we iteratively combine mutated genes belonging to the pathway so that multiple mutational events on multiple genes can be considered into one mutational event.

In some passerine bird species, differing mutations that are not clearly related suggest the likelihood of multiple mutational events.

HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.

We wished to establish whether this high prevalence is due to a genetic founder effect or to multiple mutational events.

Shortly thereafter, several groups identified FMR1 deletions in FXS patients, suggesting that multiple mutational mechanisms could give rise to the disorder [2], [3], [4], [5].

The nature of the Kelch domain and SAS1 sequence has been characterized by multiple mutational studies involving careful deletion or amino-acid substitution analysis [10] [13].

Microsatellites have many mutational biases and are known to lead to multiple mutational events (Drake 2007; Schrider et al. 2011) and to mutational nonindependence (Amos 2010a).

All other haplotypes involve multiple mutational differences (indicated by circular connections) with a maximum of 17.

Oxyradicals are involved in multiple mutational events and can contribute to the conversion of healthy cells to cancer cells.