Sentence examples for multiple mutation studies from inspiring English sources

Although the zipper region also exhibits variability, multiple mutation studies have found that it confers interaction preferences and is essential for dimerization (Reddy et al. 1992; Arsura et al. 1995; Orian et al. 2003).

In our study, combination of multiple mutation tests (KRAS or BRAF± PI3KCA) did not provide additional information over a single mutation test (data not shown).

One way around these limitations is to examine and analyze gene expression from many individual genotypes that each contains multiple mutations and to study the covariance in phenotypes and multiple gene expression levels to hypothesize which of the gene expression changes might cause phenotypic deviations [ 38- 41].

PROBLEM: Recent genetic studies link multiple mutations which impair various steps in RNA metabolism to familial neurodegenerative disease, but the great majority of patients are defined as sporadic, without any known mutation as a cause.

Seven cancer cell lines and one normal genomic DNA sample were studied with multiple mutations and polymorphisms identified among the 10 genes.

SMS has been widely studied, with multiple mutations and the associated phenotypes comprehensively described as well as a vast amount of information on the importance of this molecule in brain development [ 22- 25].

The fact that S768I showed high frequencies in multiple mutations suggests a rationale for specific studies designed to explore the role of S768I in NSCLC oncogenesis.

Whether or not this is the case will likely become clearer as more studies are published, with some insight already having been provided in a similar study in which multiple mutations in NCP1L1 and HMGCR were considered in concert using a genetic score approach to explore the impact of combination therapy with statins and ezetimibe on CHD risk [ 10].

In this study, we designed multiple mutations in the edge strands of β1 to create proteins with a stability range comparable to that of the set of central mutants.

This was underscored by 13 cases showing 2 mutations within the same paraffin block and other studies have also reported multiple mutations per primary tumor [ 21, 27, 29].

LRRK2 is better studied in neurons, because multiple mutations of LRRK2 cause familial Parkinson's disease (PD) (Zimprich et al., 2004; Paisan-Ruiz et al., 2004).