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This model is supported by neighbor joining trees constructed from multiple mutation datasets (SNVs, indels, CNAS, and SVs).
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Here, our algorithm outperforms SIFT, PolyPhen-2 and Mutation Assessor across all mutation datasets.
One would need to model datasets in which multiple mutations occurred within the same gene along with the complex and realistic LD relationships for markers around each mutation.
Adaptive evolution of multiple traits through multiple mutations at a single gene.
Many human diseases are caused by multiple mutations.
A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci.
Complex traits can require the accumulation of multiple mutations that are individually deleterious.
This technology also has the capability to correct multiple mutations simultaneously, which will be crucial to curing diseases that arise by more than one genetic mutation.
Chronocoordinate multiple mutations that span multiple kilobases [9].
There is no direct evidence for multiple hits on the Cave Bear dataset (no site with more than two nucleotide variants), which is probably due to the high transition transversion bias thereby making such multiple mutations on a site not readily apparent.
Are multiple mutations required?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com