Sentence examples for multiple mutation clusters from inspiring English sources

In the remaining cases, multiple mutation clusters corresponding to different subclones were detected in the primary sample.

There were multiple mutation clusters involving chromosomes 3, 4, 8, 10, 11, 12, 20, and 21 each of which spanned shorter distances than the major cluster in PD4107a.

Genetic selection of cotransin-resistant cancer cells uncovered multiple mutations clustered near the lumenal plug of Sec61α, thus revealing cotransin's likely site of action.

Repair of double stranded DNA breaks can expose long patches of single stranded DNA with multiple deaminations leading to the mutation clusters observed in association with genomic rearrangements in breast cancer genomes (Nik-Zainal et al., 2012; Roberts et al., 2012; Taylor et al., 2013).

In five out of eight cases, the primary sample was characterized by up to four mutation clusters, thus indicating the existence of multiple (sub clones.

This result suggested accumulation of DSB-induced mutations throughout oocyte aging as the mechanism underlying the formation of maternal mutation clusters.

Different numbers of mutation clusters were present in individual patients with a median of 11 (ranging from 2 to 26) clusters per patient.

We now discuss two examples of mutation clusters.

Recently, Wagner proposed a method to detect such mutation clusters.

(E ) Detailed view of AID* mutation clusters.

Not surprisingly, treatment with MMS or UV leads to a further 10-fold increase in mutagenesis, but in addition, in the region that has been rendered single-stranded prior to treatment, mutations occur in widely separated clusters of multiple mutations.