Sentence examples for multiple mutant data from inspiring English sources
Lastly, despite the power of yeast genetics, the interpretation of double or multiple mutant data is difficult as every mutant creates a pathological state and a function of a protein under these conditions may not necessarily reflect such a function in wild-type cells.
The power of this study derives from the authors' ability to utilize yeast knockout strains to study the role of specific repair proteins within the genesis of kataegic mutations, and to obtain whole-genome sequencing data from multiple mutant yeast clones.
To address this problem we use a parameter ensemble approach, where we for each model extract a number of parameter sets, chosen for the ability of the model (simulated with such a set of parameter values) to explain data from multiple mutant experiments [ 25].
It can be subdivided into two main approaches: either the network reconstruction is based on metabolite level correlation of multiple mutant and wild type samples, or on data from only one sample by using information of common reactions or similarity between metabolites.
We tested if hybridization of DNA from multiple mutant lines that exhibit a phenotype of interest could provide convergent data to identify the mutated region responsible for the phenotype and limit that region to the fewest gene models.
Our data indicated this tumor had a monoclonal origin from an ancestral cell with multiple mutant driver gene candidates that could generate the hallmarks of cancer [ 36], which fit best with the clonal evolution model.
3.25pm BST Government data continued... Heather Brooke describing "mutant" data – particularly health: "Huge number of datasets collected about health".
Among the multiple mutant phenotypes, pathogenicity-defective mutants were our primary focus in this study.
LvdP contributed deletion mutant data.
Multiple mutant versions of Cas9, including Cas9D10A, Cas9H840A, and a Cas9D10A,H840A double mutant, were tested.
Photoreceptor mutants were crossed with bas1-2 sob7-1, and multiple mutant combinations were isolated in F2 populations.
