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There is thus significant reason to develop multiple murine strains, which manifest, to different extents, SS-like disease manifestations.
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SNP data were filtered in our studies to include polymorphic sites for which multiple distinct murine strains in the repository encoded the minor allele in homozygous form.
Each of 256 possible quartets was assembled and frequencies collated among homozygous SNPs for 17 murine strains in which 1) complete genomic sequence data were available and 2) multiple strains were homozygous for the minor allele at a specific position (see Materials and Methods).
The conventional approach to investigate genotype phenotype relationships has been the generation of gene targeted murine strains.
Inoue et al. demonstrated that disease models and murine strains used in experimental conditions have to be taken into account to explain reported discrepancies [38].
Thymidine concentrations determined in the plasma of 7 murine strains and one rat strain were between 0.61 ± 0.12 μM and 2.04 ± 0.64 μM, while the concentrations in 22 tumour models ranged from 0.54 ± 0.17 μM to 20.65 ± 3.65 μM.
Yagi et al. showed that ICOS expression varies between numerous murine strains and there is a positive correlation between ICOS expression and IL-4 production across strains [23].
The murine strains (DBA, CBA, Balb/c, etc).
Our hypothesis was that murine strains exhibit different cardiac/genomic responses to specific pathogens.
We compared MAPK activation by CS exposure between two murine strains with different susceptibility to emphysema.
o – M. Cosio, MG-U74Av2, lung tissues, murine strains NZW and AKR.
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