We find that miR-494 is up-regulated, as part of an miRNA megacluster, in multiple mouse tumor models and clinical human HCC samples.
Recently, small-molecule inhibitors of BET proteins, for example, JQ1 and I-BET, were found to be effective inhibitors of multiple types of mouse tumors, including a NUT midline carcinoma, leukemias, lymphomas and multiple myeloma (Filippakopoulos et al., 2010; Dawson et al., 2011; Delmore et al., 2011; Zuber et al., 2011).
Focusing on epigenetic regulators, we identified WDR5, a core member of the COMPASS histone H3 Lys4 (H3K4) MLL (1 4) methyltransferase complex, as a top tumor maintenance hit required across multiple human and mouse tumors.
Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors.
This study demonstrates that bone marrow directly promotes metastasis to distant sites from tumor cells residing in the bone marrow in multiple types of tumors and multiple mouse strains.
Importantly, RK-33 in combination with radiation induced tumor regression in multiple mouse models of lung cancer.
Notably, RK-33 in combination with radiation induced tumor regression in multiple mouse models of lung cancer.
The xanthenone derivative compound DMXAA (Vadimezan, 5,6-dimethylxanthenone-4-acetic acid; Figure 1A) was initially identified as a small molecule that exhibits immune modulatory activities through the induction of cytokines and disrupts tumor vascularization in multiple mouse models (Baguley and Ching, 2002).
Multiple mouse models with targeted deletion of Brca1 in the mammary gland generate tumors with low penetrance [ 14].
Significant overlapping among transcriptomes of mouse tumors, serum, salivary glands and saliva suggests that salivary biomarkers have multiple origins.
