Direct comparisons have been made between multiple mouse tissues [ 21], between human and mouse brains, and between human blood and brain tissue [ 4].
Collectively, experiments analyzed in this report have evaluated the effects of CR in 17 mouse tissue types, and the effects of aging in 22 mouse tissue types.
The organization of these tissues is not prescribed: there can be multiple organs or multiple tissue types within one organ.
We compared three housekeeping genes in terms of the abundances of their transcripts for multiple types of mouse tissue and analysed Igf2 expression in terms of the proportion of the promoter-specific transcript in the total Igf2 transcripts.
However, many of these paralogs were expressed in multiple tissue types and multiple developmental stages.
Many miRNAs were detectable in multiple reproductive tissue types.
Transcript levels for p21, p16, p53 and pmaip1 demonstrated increased levels in multiple tissue types in the old mice, while an increase in transcript levels for gadd45a, bbc3, tnfrsf10b and bok was only observed in old skeletal muscle.
Our observation may provide valuable information for exploring such relationship of multiple tissue types.
The formation of multiple tissue types and their integration into composite tissue units presents a frontier challenge in regenerative engineering.
"In multi trauma incidents, maybe due to a blast, you might have to generate multiple tissue types," he said.
