Sentence examples for multiple mouse studies from inspiring English sources

For multiple mouse studies, two male and two female mice were used in each experiment (C57Bl/6J; n = 28; 6-12 weeks).

Although genetic alterations of AKT are relatively rare in human cancers, multiple mouse studies have demonstrated that the expression of constitutively active AKT isoforms is sufficient to drive tumourigenesis (Mende et al, 2001; Majumder et al, 2003; Tan et al, 2008).

In a recent study (Zhou et al., 2010), the authors defined the mechanism by which ActRIIB and its ligands regulate cachexia by studying multiple mouse models of cancer.

Future studies using multiple mouse models and in vitro approaches are required to address these challenging questions, which will ultimately lead to a more comprehensive understanding of how the Skp2SCF complex is regulated and its roles in cancer progression and metastasis.

To circumvent the problems inherent in transgenic mouse studies, analysis of multiple lines of transgenic mice with different copy numbers is necessary.

Although, the role of NF-κB signaling in SCC development remains to be determined, activation of this pathway in multiple mouse models of SCC warrants further study of NF-κB as a potential therapeutic target.

In contrast, our study, which utilizes multiple mouse models, unveils that CCL2 regulates several suppressive functions of MDSCs with consequences for both the innate and adaptive immune contribution to colorectal tumorigenesis.

Indeed, phenotypes measured in multiple mouse strains can be used in GWA scans (genetic mapping studies similar to GWA studies in humans) to identify disease-causing genetic variants.

There are multiple studies indicating such changes, including in vivo mouse studies [ 30].

Therefore, mouse studies can map deficits across multiple levels from altered behavior, anatomical and physiological changes to molecular disturbances.

A study of mouse brain regions in multiple mouse strains found that region specific transcription was mainly trans regulated whilst strain specificity was mainly cis regulated [ 20].