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Two genes whose expression is not correlated (no different than random) have a correlation coefficient of 0. In cases where multiple mouse paralogs for a single fly gene are present, each paralog was queried separately.
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Previous studies have focused on mouse paralogs, rat paralogs, and mouse-rat homologs, but not mouse-rat orthology, because orthologs cannot be unambiguously assigned due to excessive lineage-specific duplications that obscure orthologous relationships.
Information on human and mouse paralogs was taken from Ensembl Release 52 [ 21] with the BioMart tool.
Based on phylogenetic analyses, we propose that the ancestral tetrapod and teleost Ugt1 clusters contained multiple Ugt1 paralogs.
Although Drosophila proteome contains multiple Toll paralogs, Toll-1 is, so far, the only receptor to which an immune role has been attributed.
In several archaeal species, multiple MCM paralogs have been identified.
In any case these findings raise the interesting question of why fish possess multiple perforin paralogs.
It is noteworthy that zebrafish have retained multiple apolipoprotein paralogs over millions of years of evolution.
Our analysis indicates that protostome genomes have a single GATA123 ortholog, but multiple GATA456 paralogs.
For instance, p5, when they said that "multiple MCM paralogs have been identified in archaeal species".
If true, we predict that multiple older paralogs are coexpressed in the embryonic spinnerets and silk glands in spiders.
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