Histopathological changes such as vacuolization, observed in multiple mouse organ systems as early as the first month of age, become more prominent over time.
In this study, we showed that several mouse organs express multiple prominin-1 splice variants on mRNA, indicating that these different variants probably have partially overlapping functions.
A few examples of the results are shown in Figure 4. Whole embryos and multiple adult organs from wild-type mice showed strong staining, whereas those from Cmah-null mice showed no staining (Figure 4A).
In summary, nano-TiO2 exhibited toxicity in multiple organs in mice after exposure through i.p. injection and gavage.
The R-spondin receptor Lgr5 is a stem cell marker in multiple organs in mice and humans.
As a matter of fact, deficiency in Treg results in a fatal autoimmune syndrome affecting multiple organs in mice [ 19, 20] and humans [ 21, 22].
These mice also develop autoimmune inflammatory disease in multiple other organs including the lungs and intestine [51].
TGFβ1-deficient mice exhibit inflammation in multiple organs, succumbing to multifocal inflammation and autoimmune disorders in the internal organs (Shull et al., 1992; Kulkarni et al., 1993).
At 5 days after exposure to 107, 106 or 105 EID50 of each H9N2 isolate, viruses were detected in multiple organs of the mice, including hearts, livers, spleens, lungs and kidneys.
The reason real-time PCR was employed was that we wanted to simultaneously detect and quantify transgene-derived IL-32α in multiple organs of Tg mice.
