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The drug-target pairs in multiple motif are just shown in formula 5 in previous section.
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Transfac IDs are obtained from TRANSFAC database [ 37] Multiple motifs are often identified by iTriplet for real biological sequences.
We conclude that multiple motifs are required to mediate recognition by the APC/C and these change as cells progress through mitosis.
Several instances were noted of protein models where multiple motifs were contained within a single exon, or closely spaced exons with EST support.
The distance between multiple motifs is similarly distributed among the PUM1 and PUM2 mRNA targets ranging up to 4000 nts with median distances of 324 nts and 230 nts for PUM1 and PUM2 targets, respectively (Figure 3D).
For some miRNA families, multiple motifs were significantly enriched (E ≤ 0.001) and are shown separately.
Although XRE and other motifs are rarely found together in the promoter regions of the same gene, the mechanism of selection for AhR binding among multiple motifs was not investigated.
The rationale behind looking for over-represented motifs is that, in eukaryotes, transcription-related regulatory motifs are repeated many times in the upstream regions, and multiple copies of the motif are correlated with transcriptional activity [ 26, 27].
Rather than that, there are combinations of multiple motifs which are specific.
In vivo import analysis suggests that multiple FGLK motifs are functionally redundant.
Multiple ABRE motifs are necessary for the expression of ABA-inducible genes in seeds and vegetative tissues.
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