One tumor was classified as having complex histopathology with multiple morphological features.
Although this hypothesis has yet to be subjected to rigorous testing, multiple morphological features have been proposed to have fostered the coexistence of these herbivores.
In one report analysing the effect of multiple morphological features of oocytes on further development, only drastic morphological alterations (broken or empty zona pellucidae) were regarded as unsuitable for ICSI (Loutradis et al., 1999).
However, it is unlikely that a single, simple metric will suffice for analyzing multiple, distinguishable morphological features, each of which requires different measurements to quantify and characterize.
As a player in multiple pathways controlling many morphological features, one could predict that Hsp90 would control the variability of many different adult phenotypes, which become more variable as Hsp90 (and Hsp90 target function) is reduced.
Ward's clustering method has been used successfully by previous studies to define neuronal classes based on multiple electrophysiological, molecular, and/or morphological features (Tamas et al. 1997; Cauli et al. 2000; Karube et al. 2004; Dumitriu et al. 2006; Gallopin et al. 2006; Halabisky et al. 2006; Dávid et al. 2007; Andjelic et al. 2008; Helmstaedter et al. 2009; Karagiannis et al. 2009).
These methods, however, share one common drawback, that is they cannot obtain in situ quantitative information with morphological features for multiple biomarkers.
In contrast, two neoplasms with serous papillary and mixed mullerian morphological features shared multiple complex changes as well as cytogenetic evidence of intratumoral heterogeneity.
In our experience, the typical morphological features of myotubes, multiple nuclei and longitudinal cell growth, do not necessarily indicate sufficient dystrophin expression.
Fibroblasts isolated from diabetic ulcers display diminished proliferative capacity and abnormal morphological features, such as multiple lamellar and vesicular bodies, an absence of microtubular structures, and enlarged, dilated endoplasmic reticulum, indicative of a hypertrophic phenotype [ 61].
We confirmed that the cultured cells had the morphological features of myotubes of multiple nuclei and longitudinal growth.
