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During Mtb infection, multiple molecules and their associated signaling pathways in macrophages are involved in the regulation of cellular fates of host cells.
This approach is complementary to other methods recently appearing in the literature; it is targeted for systems with pores that are well defined, large enough to host multiple molecules, and energetically uncorrugated in the interior.
Even though the process now appears likely to involve cooperative interactions among multiple molecules and multiple regions of the Xist RNA, it is unclear which interactions are direct and which are mediated by other molecules.
The presence of multiple molecules and signaling pathways that are overrepresented in HCC cells with high metastatic potential suggests that HCC metastasis is a complex process and that the biological strategies for HCC metastasis treatment should be customized.
This analysis does not distinguish between single molecule events and those emanating from multiple molecules and the usual experimental precautions must be taken to ensure single molecule detection [ 1].
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Moreover, averaging over multiple molecules here and in Zhou et al. (2011) likely conceals transitions between SSB-ssDNA wrapping intermediates.
Cell fate determination of the respiratory epithelium is under the concerted action of multiple molecules (Morrisey and Hogan, 2010; Whitsett et al., 2011).
POMC is a polypeptide precursor of multiple molecules, including ACTH and melanocyte-stimulating hormones (MSH) α, β and γ [ 75].
Chronic lead exposure results in decreased nitric oxide and impaired nitric oxide signaling, alterations in vasoactive prostaglandins, alterations in the renin angiotensin system, and alteration of multiple molecules involved in endothelial and vascular function in vitro and in vivo in rats (Rodriguez-Iturbe et al. 2005; Vaziri 2008).
Of interest, however, reports from our lab as well as others have indicated that the requirements for ZAP-70, LAT, and SLP-76 are partially reversed by inactivation of c-Cbl (Cbl), an E3 ubiquitin ligase that targets multiple molecules for ubiquitination and degradation.
That multiple molecules of ligand and protein can be involved in some cases is supported by earlier structural work with myristoyl-CoA and human cytosolic liver ACBP [ 50].
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