Recent evidences suggested that several miRNAs including miR-29s regulated multiple molecular components of the cell adhesion machinery and contributed to functional key regulators of adhesion-associated processes (Valastyan and Weinberg, 2011).
Other up-regulated genes encode molecular regulators of energy metabolism.
Animal longevity is controlled by multiple molecular mechanisms, involving genes such as the silent information regulator SIRT1 (Bordone & Guarente, 2005), superoxide dismutases (SOD1 and SOD2; Fabrizio et al., 2003; Parker et al., 2004), p66Shc (Migliaccio et al., 1999; Pinton & Rizzuto, 2008), as well as insulin and insulin-like growth factor-1 (IGF-1; Yang et al., 2005).
Classical miRNAs are master regulators of human cancer metastasis, by targeting multiple molecular pathways involved in each step of this complex phenomenon [ 144 ].
A number of key genetic and molecular regulators of yield component traits, especially seed size and number, have been identified.
Isatins have multiple molecular mechanisms to exert their anticancer activity.
MTA may have multiple molecular and cellular targets.
Almost all nuclear proteins were annotated with multiple molecular functions.
Complex interactions have been reported between molecular regulators of endothelial function [12].
Apoptosis and autophagy share common molecular regulators and signaling pathways.
