Koninki K, Barok M, Tanner M, Staff S, Pitkanen J, Hemmila P, et al. Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells.
Putting this together, since the same phenotypes can have multiple causes including different gene mutations, there must be multiple molecular mechanisms causing ALS and ALS is a syndrome.
In this Review, we discuss the multiple molecular mechanisms of p53 regulation and how they modulate the induction of apoptosis or cell cycle arrest following DNA damage.
Pathogens employ multiple molecular mechanisms of adhesion to initiate infection and effective anti adhesion drugs may probably have to consist of a cocktail of inhibitors.
We found that these phenotypes could be rescued by intervening in numerous biological pathways, including IGF-1/insulin signaling, mitophagy, and the mitochondrial unfolded protein response, suggesting that it may be possible to ameliorate mtDNA disease through multiple molecular mechanisms.
In addition, comparison of the SMYD2 ERα and SMYD2 p53 structures provides the first structural insight into the diverse nature of SMYD2 substrate recognition and suggests that the broad specificity of SMYD2 is achieved by multiple molecular mechanisms such as distinct peptide binding modes and the intrinsic dynamics of peptide ligands.
Isatins have multiple molecular mechanisms to exert their anticancer activity.
The remarkable ability of our vision to function under ever-changing conditions of ambient illumination is mediated by multiple molecular mechanisms regulating the light sensitivity of rods and cones.
This study indicates that multiple molecular mechanisms, including gating abnormalities, trafficking defects, or a combination of both, are responsible for SCN5A-related familial SSS.
Depending on the cell type, death stimulus, and experimental conditions, multiple molecular mechanisms of mitochondrial dysfunction may co-exist involving the cyto c release, permeability transition pore (PTP) complex activity, and the BAX/BAK pore-forming properties [26], [27], [35] in causing the MOMP.
It has been shown that BT-ICs are more resistant to chemotherapy than non-BT-ICs due to multiple molecular mechanisms [10], including overexpression of ATP-binding cassette transporters [11] and enhanced ability of surviving [12], [13] and DNA damage repairing [12], [13].
