Sentence examples for multiple molecular effects from inspiring English sources

Multiple molecular effects were observed during osajin treatment including a significant loss of mitochondrial transmembrane potential, release of cytochrome c into the cytosol, enhanced expression of Fas ligand (FasL), suppression of glucose-regulated protein 78 kDa (GRP78), and activation of caspases-9, -8, -4 and -3.

For both cytostatics multiple molecular effects are known.

Further preclinical experiments will have to elucidate the multiple molecular effects of rhEPO and the interaction with RT on tumour cells, neoplastic endothelium, and normal endothelium.

While multiple molecular effects of arsenite toxicity have been accumulated in the literature, increased oxidative stress by inadequate detoxification of reactive oxygen species (ROS) or increased formation of these has been repeatedly observed (Smith et al., 2001; Miller et al., 2002; Shi et al., 2004; Cui et al., 2008).

Thus, owing to this multifunctionality, DCN may exert its anticancer effects through multiple molecular approaches that all contribute to varying degree to its biological effects on cancer cells and tumor environment [ 6].

It is clearly understood that typical clinical outcomes of metabolic diseases, like infarctions in coronary heart disease, occur as a result of life-long effects of multiple molecular pathways.

Among the features Meredys was designed to tackle are the accurate simulation of reaction-diffusion systems operating in three dimensions, the potential for multi-state, multi-component molecular species, and the effect of multiple molecular states on the rate and outcome of the reactions these molecular species undergo.

Synergistic anti-tumor effects have been noted in vitro for the combination of retinoid and tamoxifen and multiple molecular mechanisms for the ligand effects have been reported [ 20, 21].

We show that genes that have been demonstrated to have a measurable effect on multiple molecular phenotypes show higher rates of protein evolution than genes having an effect on a single category of phenotype.

Moreover, two of these, levosimendan and pimobendan, have multiple molecular targets and other pharmacologic effects in addition to inotropy, such as peripheral vasodilation.

While understanding how the single endpoint of in vitro inhibition compared to in vivo change is a standard part of the integrated preclinical risk assessment, 70 now in silico predictions allow assessment of the combined effects on multiple molecular targets.