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This effect would complement that of ATP synthase dimers on membrane curvature, in a feed forward loop that ultimately leads to stabilization of cristae shape by its multiple molecular determinants.
The Gram-negative cell envelope presents a complex barrier to hydrophilic solutes and contains multiple molecular determinants of antibiotic susceptibility and resistance.
It is thus tempting to conclude that host specificity of S. pneumoniae is defined by multiple molecular determinants.
For example, genome-wide association studies have identified multiple molecular determinants of diseases [ 5] and the analysis of disease symptoms from medical patient records has been shown to be able to capture disease comorbidities, predict disease progression and, most interestingly, molecular causes of diseases [ 6, 7].
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A cancer ontology slim represents a subset of specific cancer-related ontology terms that can be used to perform meta-analysis across multiple cancer types to identify driver genes and other molecular determinants (25).
Several studies to date have demonstrated that HDACi induce alterations in the expression of multiple drug targets and/or metabolic pathways that are critical molecular determinants for cancer therapeutics.
Complete genome level analyses of multiple carriage strains of S. aureus will be important in clarifying molecular determinants of S. aureus nasal carriage.
We assume that the identified molecular determinants may be prioritized for further screening as novel drug targets to cure multiple ARDs.
Together, these results provide new insights to the molecular determinants of differential signaling of the AT1R and further support the existence of multiple signaling states.
Though it is now generally recognized that multiple signaling conformations exist and may be physiologically relevant for a number of 7TMRs [6], [6], the molecular determinants underlying specific G protein or β-arrestin interactions remain largely unresolved.
A systematic characterization of S. sclerotiorum transcriptome on multiple hosts and the functional analysis of differentially regulated effector genes should prove useful to decipher the molecular determinants of quantitative disease resistance and host range in this fungal pathogen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com