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The innate biological response to peripheral nerve injury involves a complex interplay of multiple molecular cues to guide neurites across the injury gap.
The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues.
Therefore what determines the success of each step is the ability of EPCs to interact, adapt and respond to multiple molecular cues present in each compartment.
Despite the expression of so many different integrin subunits by EPCs, it is apparent that some of these integrins can in fact be activated and/or upregulated at specific steps of EPC biology as reflex to the multiple molecular cues (tissue specific ECM and soluble factors) that may be present.
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One of the goals of synthetic biology is to develop programmable artificial gene networks that can transduce multiple endogenous molecular cues to precisely control cell behavior.
Multiple molecular and physical cues engage in complex interplay to afford the fine control over stem cell behavior that is required during tissue development, homeostasis, and repair.
Both concepts consider that tumors originate from single cells that have acquired multiple molecular alterations, have developed indefinite proliferative potential, and assume that (micro environmental cues have an impact on the composition of a cancer.
These studies demonstrate the complex crosstalk relying on multiple cytokines and resulting in a permissive niche that will provide all molecular cues for maintenance and expansion of ovarian cancer stem cells.
As increasing numbers of ligands for Ntn1 receptors are identified, this has led to an appreciation of the diversity of molecular cues available to direct brain wiring and invites broader consideration about how receptors integrate signals from multiple ligands during circuit formation and other developmental processes.
Here, we summarize these molecular cues and divide them into three main groups.
Distinct molecular cues are involved in different developmental stages and nucleus, suggesting diverse guidance mechanisms.
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CEO of Professional Science Editing for Scientists @ prosciediting.com