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The OPG/RANK/RANKL pathway offers multiple molecular checkpoints for therapeutic targeting in osteolytic metastases [ 34].
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To this end, it has been challenging to devise effective therapies for SLE given that multiple cellular and molecular checkpoints go awry in lupus.
However, genotoxic drugs can trigger multiple molecular events including activation of p53-independent checkpoints and thus may partially protect the cancer cells during chemotherapy [ 3].
MTA may have multiple molecular and cellular targets.
Almost all nuclear proteins were annotated with multiple molecular functions.
Dysfunction of these molecular checkpoints results in the proliferation of cancer cells.
and multiple molecular pathways placed downstream.
Identification of pathways and molecular checkpoints in the pathogenesis of skeletal metastasis has led to discovery of novel molecular targets for therapeutic intervention (Table 3).
In the West Bank, Palestinian children passed through multiple Israeli checkpoints.
In the wake of numerous threats, organizers devised an elaborate scheme involving multiple security checkpoints.
Multiple HR checkpoints have been proposed as potential therapeutic targets for GBM.
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