This is a considerable period of time during which tumors with multiple aggressive characteristics, especially multiple proliferative molecular changes, may progress.
This real-time imaging study provides, for the first time, statistically significant data on simultaneous multiple molecular level changes to enable refinements and testing of models of the dynamics of mitochondria-mediated apoptosis.
To gain a global view of the multiple interrelated molecular changes that relate to the sexual dimorphism in Xiphophorus and provide a database for future studies, we initiated a transcriptome project to obtain deep coverage of cDNAs from adult fish of different gender.
Multiple molecular and cellular changes and events, each with their own threshold and dose-response, are necessary to produce the cancer or noncancer effect.
We examined whether multiple HCC has specific molecular changes that indicate the process of carcinogenesis.
The key hypothesis behind these approaches is that cancer consists of hundreds of distinct molecular changes, from multiple types of genetic and epigenetic alterations to the interactions among them.
Indeed, during the progress of depression, multiple molecular, cellular, structural, and functional changes occur in the brain.
