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First, in diseases with multiple molecular causes, such as MS, there could be more than one expression signature related to a response type of the patient (van Baarsen et al., 2006).
As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible.
Despite many studies identifying multiple molecular causes of aging like oxidative stress, senescence factors, telomere shortening, genomic instability, epigenetic changes or proteotoxicity (Harman 1956; Harley et al. 1992; Campisi 2005; Dolle and Vijg 2002; Cohen et al. 2006), the primary cause of aging of the human has not yet been determined.
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The widely varying levels and sequence requirements for efficient stop codon suppression suggest that multiple molecular mechanisms can cause readthrough in mammals.
Complicated diseases such as cancer, Alzheimer, mental disorder, and heart diseases are very complex and caused by multiple molecular abnormalities.
Complicated noncommunicable diseases such as cancer, Alzheimer's disease, mental disorders, and heart diseases are caused by multiple molecular abnormalities.
Multiple molecular, cellular, micro-environmental and systemic causes of anticancer drug resistance have been identified during the last 25 years.
Systems biology approaches hold the promise of substantially improving the current state-of-the-art in medicine by clarifying distinctions between multiple disease states and enabling the underlying molecular causes of a disease to be identified [ 6- 8].
It has become apparent that many diseases such as cancer are much more complex than initially anticipated, because they are often caused by a combination of multiple molecular abnormalities, which supports a novel network perspective of complex diseases [ 2].
The molecular causes of idiopathic short stature are multiple [ 2], as expected for a multifactorial trait that is influenced both by individual genotypes and environmental factors [ 3].
The molecular causes of idiopathic short stature are multiple [ 2], as for any multifactorial trait influenced by individual genotypes and environmental factors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com