Sentence examples for multiple molecular alterations from inspiring English sources

Pancreatic ductaladeno carcinoma (PDAC) is a deadly cancer characterized by multiple molecular alterations, the presence of an intense stroma, poor perfusion, and resistance to therapy.

Furthermore, whether and to what extent the occurrence of multiple molecular alterations affects clinical response and patients' survival is presently unknown.

In light of the occurrence of multiple molecular alterations within the same tumor, we investigated our cohort by separating patients according to the actual number of molecular abnormalities in the same tumor, i.e., none vs 1 vs ≥2 alterations.

Multiple molecular alterations and cellular pathway dysregulations may occur during disease development and progression [ 23].

Genetic heterogeneity is a feature of NSCLC, with varying combinations of multiple molecular alterations contributing to tumour development [ 1].

Ovarian cancer is a complex disease, characterized by successive accumulation of multiple molecular alterations in both the cells undergoing neoplastic transformation and host cells [ 1].

While the mechanisms resulting in T resistance are not completely understood, recent studies have identified multiple potential molecular alterations to explain in vivo lack of clinical activity.

This study demonstrates multiple additional molecular alterations amongst BRAF mutation-positive patients with advanced melanoma who achieved a CR or PR on BRAF targeted agents.

Hepatocellular carcinoma (HCC) is a heterogeneous tumor that develops via activation of multiple pathways and molecular alterations.

Multiple cellular and molecular alterations such as amplification or overexpression of oncogenes, hypermethylation or mutation of tumor suppressor genes, activation of cancer stem cells, and infiltration of immune cells, contribute to the malignant transformation of HCC.

PDAC chemoresistance is acquired through multiple molecular pathways and genetic alterations affecting cell cycle, apoptosis, and intracellular drug accumulation.