Sentence examples for multiple modifications that from inspiring English sources

Modulation of an interaction by modification of multiple residues even allows for rheostatic control of binding strength, where the affinity for an interaction partner is gradually altered by multiple modifications that additively enhance or diminish the interaction.

The apparent 'default expression' patterned by the MES-4/PRC2 antagonism is interesting, as both H3K36me areH3K27me are not noticeably affected by the observed reprogramming mechanisms, described below, that are active in Z2/Z3, even though multiple modifications that correlate with gene activation are significantly reduced.

CONCLUSIONS Over 18 months, persons with prehypertension and stage 1 hypertension can sustain multiple lifestyle modifications that improve control of blood pressure and could reduce the risk for chronic disease.

X inactivation, the silencing of one X-chromosome in female mammals, is achieved by the establishment of multiple epigenetic modifications that result in chromatin of the inactive X (Xi) being transcriptionally repressed.

The N-terminal tails of histones are subject to multiple covalent modifications that can influence gene expression locally at specific promoters or within large regions of chromatin.

A study conducted by Elmer et al. showed that, over 18 months, persons with prehypertension and stage 1 hypertension could sustain multiple lifestyle modifications that improve control of blood pressure and could reduce the risk for chronic disease [ 26].

In these ways, binding of 14-3-3s 14-3-3s 14-3-3sthe merging of signals from multiple post-translational modifications that converge on the target.

Interestingly, this domain has been proposed to function as a 'molecular switch' (Greiner and Yang, 2011) controlled by multiple post-translational modifications that can determine the fate of mhtt exon-1 either by rendering it innocuous or enhancing its pathogenicity.

The multiple types of modifications that take place on specific histone residues and the regulatory cascades that can be triggered in this manner led investigators to propose that a "histone code" regulates gene expression in a manner reminiscent of the genetic code translating nucleic acid coding sequences into protein sequences [ 1, 2].

CS structure is very heterogeneous and contains various sulfation patterns owing to the multiple and random enzymatic modifications that occur during its biosynthesis.

This strategy involves multiple and hierarchical chromatin modifications that regulate nuclear dynamics in response to a developmentally programmed signal(s), presumably of paracrine origin, before the resumption of meiosis.