Sentence examples for multiple modifications in the from inspiring English sources

Multiple modifications in the hydrogen bonding pattern to P resulted in systematic changes of the free energy gap.

Other key advantages when analyzing large molecules include an increased identification coverage and the possibility of assessing relationships among multiple modifications in the same molecule (e.g. histone; Chi et al., 2007).

Multiple modifications in order to alter the expression level of the enzymes might thus be mandatory in order to obtain the desired yield increase.

In the cases demonstrated in Figures 4 and 5, peptide-level measurements would have great difficulty to simultaneously quantify correlated changes in multiple modifications in a proteotypic (gene-specific) fashion.

However, DZNep treatment in combination with TSA resulted in considerable CLDN3 induction with changes in multiple histone modifications in the CLDN3 promoter.

Finally, our findings suggest that epigenetic therapies capable of targeting multiple histone modifications in the promoter regions of CLDN3 and CLDN4 may have the potential to treat ovarian cancer.

We suggest that despite the successful application of ETD for sequencing of several peptides with multiple modifications, the N-terminus of H3 in the primary human adipocytes is so heavily and differentially modified that its heterogeneous products did not pass the MS/MS quality criteria used for identification in this study.

Comparison of the spheroid body's genome sequence with corresponding regions of near free-living relatives indicates that multiple modifications have occurred in the endosymbiont's genome.

This is because multiple modifications are present simultaneously in the native histones, and yBRD binding to a particular acetylation site can be influenced positively or negatively by other modifications on the neighboring residues, thereby complicating the analysis of the histone binding selectivity.

However, comparative genomic analysis suggests that multiple modifications have occurred in nucleotide salvage pathways during the course of chlamydial evolution, as revealed by the variable presence of udk (uridine kinase), pyrE (pyrimidine phosphoribosyl transferase), guaB (IMP dehydrogenase), guaA (GMP synthase) and add (adenosine deaminase) in different isolates (Table 1).

In general, multiple modifications have been used, including the rational establishment of a xylose metabolic pathway and non-rational adaptive evolution to improve xylose metabolic capacity and inhibitor tolerance (Kim et al. 2013; Ko et al. 2016; Kuyper et al. 2005a; Peng et al. 2012; Van Vleet and Jeffries 2009).