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Our approach included a two-staged analysis plan that provided increased power to detect SNP associations and accounted for multiple modes of inheritance.
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Multiple modes of mtDNA inheritance have been described in mammals propagated through interspecies crossing or assisted reproduction.
Allow for multiple modes of interaction.
Apparently, DEET has multiple modes of action.
Multipoint mode-of-inheritance-free linkage analyses were performed using the GENEHUNTER software.
The model has been recently extended to make it applicable to data from multiple unlinked loci, even with different modes of inheritance [ 1].
However, multiple patterns of affection consistent with other modes of inheritance are regularly observed, including autosomal dominant (e.g., father and son) and X-linked (transmission through a female relative) inheritance.
Multiple studies have been conducted with respect to potential modes of inheritance in this breed, however results were not always consistent and this again may reflect different study design, inclusion and exclusion criteria.
The study addressed this by creating sensitivity analyses that aggregated all comparisons for different modes of inheritance with each population and applied the BH procedure for multiple comparisons.
Various modes of inheritance relationship (dominant, recessive, overdominant, additive and multiplicative) were considered in our study.
Owing to a large number of tests (269 SNPs × 3 genetic modes of inheritance), caution in interpreting the data is warranted; no adjustment was made for multiple testing because of a lack of complete independence of tests.
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CEO of Professional Science Editing for Scientists @ prosciediting.com