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Similarly, structure-activity relationships of FXR-active compounds suggest that this receptor may have multiple modes of action that modulate receptor-coregulator interactions essential to NR transactivation7.
The different potencies and multiple modes of action on nAChRs may help to better understand the pharmacology of these receptors and to aid in novel drug design.
"Prevention involves killing weeds with multiple modes of action, and preventing movement of any potentially resistant weeds from field to field, or from field margins into fields," says associate professor Thomas Bjorkman (right).
Venerate advanced bioinsecticides (Burkholderia spp. strain A396) feature multiple modes of action and are effective against a wide variety of chewing and sucking insects and mites yet are easy on beneficial insects.
In addition to the small size, potent bactericidal activity, low to moderate hemolytic toxicity and membrane disruption ability, several peptides such as C10-RIKWWK and C10-RKWWK apparently retarded the migration of DNA on agarose gel in the DNA-binding assay, which implied the multiple modes of action in their bacteria-killing mechanism.
Apparently, DEET has multiple modes of action.
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Several hypotheses have been proposed for synergistic toxicity, including multiple modes-of-action and inhibition of metabolism, but the mechanism underlying synergy has not been fully elucidated.
Discovery of new polypharmacological antibacterial agents with multiple modes of actions can be an alternative to combination therapy and also a possibility to slow development of antibiotic resistance.
Likewise, Ankley et al. [28] reported multiple modes of actions of the DMI fungicides prochloraz and fenarimol in fish.
Therefore, the use of appropriate antioxidants with multiple modes of actions, could prevent lipid oxidation and extend the shelf-life of emulsion rich in n-3 fatty acids effectively.
Functional analyses revealed clues for rice heterosis, such as multiple modes of actions and strengthening of embryo-characteristic function.
More suggestions(15)
multiple modes of interaction
multiple modes of locomotion
multiple modes of target
multiple points of action
multiple modes of information
multiple modes of simulation
multiple modes of communication
multiple targets of action
multiple modes of induction
multiple mechanisms of action
multiple sessions of action
multiple courses of action
multiple fields of action
multiple modes of inheritance
multiple modes of presence
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