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In this paper, a constructive procedure to design functional unknown input observer for nonlinear continuous time systems under the Polytopic Takagi-Sugeno framework (also known as multiple models systems) is proposed.
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Multiple model systems including mouse cell lines expressing SS18-SSX, and genetically engineered mouse models of synovial sarcoma have been developed to elucidate the role of the chimeric gene in synovial sarcomagenesis.
Importantly, this Tip60 complex is evolutionarily conserved from Saccharomyces cerevisiae to Drosophila to humans [4], [5], [6], making it amenable for functional characterization using multiple model systems.
This 'signaling cassette' is highly conserved in evolution, and many of the discoveries piecing together the molecular connections between components of this cassette were concurrently performed in multiple model systems such as Drosophila and mice, leading to equivalent results.
This may be a factor in arsenic-induced CSC overabundance seen in multiple model systems.
Multiple model systems have been developed to elucidate the molecular functions of MeCP2 and the etiology of RTT disease.
Hence, prediction of lncRNAs' functions with multiple model systems provides guideline for further experimental investigations [ 7, 8].
Our study is the first to identify and characterize genes involved during wound healing in Nematostella and is relatable to multiple model systems of regenerative biology.
Targeting the key steps in the glycolytic pathway of cancer cells has been shown to produce strong anticancer effects in multiple model systems [ 8, 53- 56].
However, considering the evidence from multiple model systems (discussed above) it is clear that these effects are mediated through HA receptors.
Caloric restriction, limiting calorie intake without causing malnutrition, has been shown to extend lifespan in multiple model systems (de Magalhaes et al. 2012; Masoro 2005; Spindler 2010).
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