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This concept would be consistent with previous studies in multiple models demonstrating that necrosis is an ancient, genetically programmed cell-death pathway distinct from apoptosis and sensitive to specific stress events [ 43].
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The consensus model by integrating the outputs from multiple individual models demonstrated better predictivity ((q_{ext}^{2}) = 0.669 0.689) than any individual model for the test set.
Evidence from multiple animal models demonstrates that testosterone plays a crucial role in the progression of symptoms in spinal and bulbar muscular atrophy (SBMA), a condition that results in neurodegeneration and muscle atrophy in affected men.
A multiple regression model demonstrating the order of importance of the five parameters in relation to relative attenuation was developed.
Although multiple cell culture models demonstrated oncogenic potential of several HCV proteins, most transgenic mouse models expressing these proteins did not develop HCC [2].
Our data in four isogenic models together with analysis of publicly available data sets assessing multiple non-isogenic models demonstrates that MMR selectivity of cytarabine in epithelial and haematological cancer cells is a relatively robust effect, and provides greater impetus that cytarabine should be assessed clinically in patients with MMR-deficient malignancies.
The VICs generated 100 3000 nN/cell after one week of culture, and multiple regression modeling demonstrated, for the first time, quantitative interaction (synergy) between these factors in a three-dimensional culture system.
While rodent models demonstrate multiple levels of congruence with human brain aging, significant differences exist in life history evolution, dietary energy sources and utilization, reproductive aging, and temporally accumulated stochastic events.
Multiple genetically engineered animal models demonstrated the importance of augmented proliferation on cyst development.
Studies in multiple model systems demonstrate that epigenetic modifications are important along the entire gene, including untranslated regions (Einstein et al. 2010; Fu et al. 2006, 2009).
Using data from mammals, phylogenetically corrected general linear models demonstrate that both multiple paternity and alpha paternity, but not extra group paternity, relate to testes size.
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