Sentence examples for multiple model systems from inspiring English sources

The work also uses multiple model systems including cell culture, rodents, non-human primates, and human investigation.

These three proteins share several features, including the presence of a bioinformatics-predicted prion domain, aggregation-prone nature in vitro and in vivo and toxic effects when expressed in multiple model systems.

We previously described a strong genetic interaction between Ypk9 and another Parkinson's disease (PD) protein α-synuclein in multiple model systems, and a role for Ypk9 in manganese detoxification in yeast.

The connection between FUS function and DNA ligation defects was examined in multiple model systems, including CRISPR/Cas9-mediated FUS knockout (KO) cells, familial ALS patient-derived induced pluripotent stem cells (iPSCs) with FUS mutations, motor neurons differentiated from these patient-derived iPSCs, and spinal cord tissue with FUS pathology from ALS patients.

Multiple model systems including mouse cell lines expressing SS18-SSX, and genetically engineered mouse models of synovial sarcoma have been developed to elucidate the role of the chimeric gene in synovial sarcomagenesis.

Importantly, this Tip60 complex is evolutionarily conserved from Saccharomyces cerevisiae to Drosophila to humans [4], [5], [6], making it amenable for functional characterization using multiple model systems.

In this paper, a constructive procedure to design functional unknown input observer for nonlinear continuous time systems under the Polytopic Takagi-Sugeno framework (also known as multiple models systems) is proposed.

To deal with the uncertainty of plant-model matching conditions needed for adaptive control, multiple reference model systems are employed to generate multiple parameter estimation and feedback control signals from which a most suitable control input is selected by a control switching mechanism designed using multiple estimation errors.

Further, when multiple model organism systems are being used simultaneously, the taxa of the genes being investigated is not always specifically designated.

Spina, C. A. et al. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.

Transcriptional dysregulation occurs early in the molecular pathology of HD and has been recapitulated across multiple HD model systems (reviewed in [10]).