Exact(1)
Mia40 likely acts as a chaperone for a subset of substrates that reside in multiple mitochondrial subcompartments upon their initial entry through the TOM complex.
Similar(59)
The majority of the precursor proteins are sorted into the mitochondrial subcompartments via five distinct routes.
DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.
This peculiar architecture is of pivotal importance for multiple mitochondrial functions.
Multiple mitochondrial and nuclear genetic loci were sequenced (Supplementary Table 8) and 13 microsatellite loci (Supplementary Table 9) were amplified and genotyped.
Mitochondrial functions are dependent on a biogenesis process that delivers proteins by a specific protein import reaction, comprising three separate biochemical processes (recognition, translocation to mitochondrial subcompartments and processing).
To check Erv1 localization in the mitochondria, we tested the proteolysis susceptibility of Erv1 and mitochondrial marker proteins in each of the mitochondrial subcompartments.
This provides definitive evidence that T3 renders the proteins of the mitochondrial subcompartments more vulnerable to oxidative damage and the utilization of ROS in lipid and protein oxidation of SMP is reciprocal in altered thyroid states.
It is thus possible that PINK1 senses localized mitochondrial damage or damaged mitochondrial subcompartments in a manner similar to that by which it regulates mitophagy via mitochondrial import deficiency, but rather than degrade the entire organelle, MDVs are generated to specifically remove the damaged segments.
We emphasize that multiple mitochondrial signaling pathways, besides mitochondrial ROS, can induce cellular senescence.
Prioritizing which nuclear-encoded mitochondrial maintenance genes to screen in adults with multiple mitochondrial DNA deletions is challenging.
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