Many of these genes were involved in multiple aspects of cellular homeostasis and also included some key molecules in energy-consuming mitochondrial processes, such GSTT1, KCNN3, NDUFC1, S100A1, and SLC11A2 suggesting a male-specific increase in mitochondrial activity and Ca2+ homeostasis.
DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.
This peculiar architecture is of pivotal importance for multiple mitochondrial functions.
Furthermore, it is unclear whether Trak1 also functions in other mitochondrial processes besides regulating mitochondrial motility.
Functional-term-enrichment analysis identifies several important metabolic and mitochondrial processes that are critical for hibernation, such as fatty acid beta-oxidation and mitochondrial transport.
We emphasize that multiple mitochondrial signaling pathways, besides mitochondrial ROS, can induce cellular senescence.
Each of the major mitochondrial processes is linked.
In addition, the inability to readily quantify mitochondrial fusion has made it difficult for scientists outside the field to investigate the contribution of mitochondrial fusion to multiple cellular processes.
Riboflavin (vitamin B2) is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), essential cofactors for many metabolic enzymes involved in multiple cellular processes, such as mitochondrial electron transport chain (METC) and cellular redox regulation in other cellular compartments [ 1- 3].
Mitochondrial metabolism is closely involved in multiple cell processes in immune system (MacIver et al., 2013), so we sought to understand whether Hcy-altered mitochondrial metabolism contributed to Hcy-induced T-cell activation.
