DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.
The OCR was higher in XFNG condition compared to XF after the addition of selective mitochondrial inhibitors oligomycin, FCCP, Rotenone and Antimycin A indicating higher non-mitochondrial respiration (eg. Glycolysis, fatty acid metabolism).
The transcription factor BACH1, which targets mitochondrial metabolism, is expressed at high levels in several types of cancer; reducing its expression in tumours makes them more susceptible to treatment with mitochondrial inhibitors.
This peculiar architecture is of pivotal importance for multiple mitochondrial functions.
The mitochondrial inhibitors malonate and 3-nitropropionic (3NP) acid are potent neurotoxins in vivo.
The mitochondrial inhibitors did not change NO relaxation.
We emphasize that multiple mitochondrial signaling pathways, besides mitochondrial ROS, can induce cellular senescence.
Rotenone has been widely used as mitochondrial inhibitor by reducing membrane potential and inducing mitochondrial damage.
For example, Rotenone is a potent mitochondrial inhibitor and commonly used as a pesticide.
3b N3− is a mitochondrial inhibitor, and a myeloperoxidase and catalase inhibitor.
