SPG7 is associated with multiple mitochondrial DNA deletions, suggesting that functions of other mitochondrial proteins involved in either mitochondrial DNA replication itself or pathways of mitochondrial quality control are altered (Wedding et al. 2014).
Multiple changes in mitochondrial function, structure, distribution, and dynamics contribute to aging or age-related features.
SIN3-regulated genes include those that encode proteins affecting multiple aspects of mitochondrial function, such as energy production and stress responsiveness, important for health maintenance.
More recently, LSFC fibroblasts were found to display multiple alterations in mitochondrial function and increased susceptibility to nutrient-induced cytotoxicity, particularly saturated fat (Burelle et al., 2015).
The precise mechanisms leading to its anticancer effects are not clearly established, although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed.
Then, mitochondrial functions in stress responses are queried and related functional modules in SPIN convinced us that CoreMitoP proteins participate in multiple stress responses, besides salt, cold and drought.
Therefore, we conclude that a proximal function of Parkin recruitment to depolarized mitochondria is to mediate the proteasome-dependent degradation of multiple mitochondrial outer membrane proteins.
Yet, mitochondrial RNA homeostasis is one of the key elements in regulating mitochondrial functions.
DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.
