Sentence examples for multiple mitochondrial factors from inspiring English sources

Multiple mitochondrial factors, such as excessive mitochondrial ROS production, aberrant mitochondrial dynamics, defective electron transport chain, imbalanced bioenergetics, activated AMPK, decreased NAD+ levels, altered metabolism, and dysregulated mitochondrial calcium homeostasis, contribute to the establishment of irreversible growth arrest (Fig. 1).

DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.

This peculiar architecture is of pivotal importance for multiple mitochondrial functions.

Known mitochondrial factors include AIF and HtrA2.

Biallelic mutations in IBA57, encoding a Fe/S mitochondrial protein assembly factor, can be responsible for a slowly progressive childhood-onset HSP (Lossos et al. 2015), up to multiple mitochondrial dysfunction syndrome 3 (MMDS3; OMIM #615330), a severe lethal encephalopathy with multiple malformations, myopathy and hyperglycinemia (Ajit Bolar et al. 2013).

We emphasize that multiple mitochondrial signaling pathways, besides mitochondrial ROS, can induce cellular senescence.

The mechanisms governing the coordination of the multiple transcription factors involved in mitochondrial biogenesis have been partly explained by the discovery of the PGC-1 coactivator family [1].

It has been documented that PGC-1αregulates mitochondrial biogenesis by serving as a coactivator of multiple transcription factors, such as NRF and TFAM [40], [41], [42].

Multiple environmental factors, in particular a typical Western diet, drive mitochondrial overload, while other changes in Western society, such as stress and sleep deprivation, increase insulin resistance and the propensity for food intake.

TLR4−/− mice have dysregulated immune systems such that multiple factors unrelated to mitochondrial biogenesis probably contribute to the increased mortality rate.

mitochondrial transcription factor A. factor-E2-related factor.