Exact(1)
Examination of parkin− / − mutant muscles revealed multiple mitochondrial aggregates within the cell (Fig. 3C,C′), but no obvious accumulation of intracellular αPS2 around the nuclei (Fig. 3G).
Similar(59)
DOX disrupted cardiac mitochondrial biogenesis, as demonstrated by decreased mtDNA levels and altered transcript levels for multiple mitochondrial genes encoded by both nuclear and mitochondrial genomes.
This peculiar architecture is of pivotal importance for multiple mitochondrial functions.
Increased mitochondrial aggregates were readily observed in diabetic cumulus cells as compared to controls (Fig. 3).
Co-localization experiments demonstrated neurons with mitochondrial aggregates often had increased ubiquitin immunoreactivity (Fig. 3l n), but the mitochondrial aggregates themselves were not ubiquitinated.
The mitochondrial aggregates were only present in iTDP-43WT mice at 2M of age or younger.
TUNEL-positive nuclei were also absent in EPCD cells that contain stage M2 mitochondrial aggregates.
Symptomatic mice from both founder lines showed the highest frequency of mitochondrial aggregates (Supplementary Fig. 5).
Mitochondrial aggregates, as well as individual chloroplasts were subsequently seen undergoing Brownian motion in the vacuole.
The mitochondrial abnormalities obtained through loss of PINK1 function consist of mitochondrial aggregates, swollen or enlarged mitochondria and the presence of a tubular mitochondrial network within the cells.
We emphasize that multiple mitochondrial signaling pathways, besides mitochondrial ROS, can induce cellular senescence.
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