These PDZ domains were arrayed onto aldehyde-presenting flat glass slides, and multiple identical microarrays were printed in a 96-well plate-like format [ 97, 98].
On the other hand, real-time DNA microarrays are capable of taking multiple temporal samples of a binding process [7 9].
Therefore, reuse, pooling, and integration of multiple microarray dataset are attractive approaches.
Extensive expertise, laser-capture microdissection, and multiple microarray platforms are available.
Pooling and integration of multiple microarray dataset are attractive to increase the number of sample in order to enhance statistical power.
First, signal intensities and enrichment scores for GSTFs that have been measured in vitro on multiple protein binding microarrays were averaged within each of the two datasets.
The average expression value of a gene in multiple microarray replicates was used to represent the expression value of the gene under the treatment.
The only pro-apoptotic gene consistently upregulated across multiple microarray analyses is the BH3-only BCL-2 family member BIM, and it has been shown that BIM has a critical role in glucocorticoid sensitivity and resistance [ 37], although in this current study BIM was only induced 1.3 fold.
Genes with multiple probes in the microarrays were selected if at least one probe presented an FDR < 0.1 for the interaction term.
Multiple microarray datasets were analyzed to determine the correlation between FoxM1 and PTTG1 mRNA levels.
