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However, because multiple mice strains were used for developing the TTG mice, little MHC minor differences can not be totally excluded (for Balb/c MHC-I, H-2K[d] <2% by flow cytometry).
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For example, multiple mouse strains have to be tested to recapitulate genetic regulation of immune tolerance in humans.
This study demonstrates that bone marrow directly promotes metastasis to distant sites from tumor cells residing in the bone marrow in multiple types of tumors and multiple mouse strains.
This result highlights the strain-specificity of dietary responses, which challenges efforts to construct general models of dietary response that will have applicability to multiple mouse strains, to other species, and potentially, to humans.
These results are in agreement with those presented by Shockley et al. [15], and suggest that increased expression of genes involved in immune system processes is a major feature of the hepatic response to HF diet, which occurs robustly in male and female mice and among multiple mouse strains.
Multiple mouse strains are available, with slight differences in immunosuppression conferring both advantages and disadvantages.
A study of mouse brain regions in multiple mouse strains found that region specific transcription was mainly trans regulated whilst strain specificity was mainly cis regulated [ 20].
In mice, Apoa2 b allele, characterized by Ala61-to-Val61 Ala61-to-Val61 Ala61-to-Val61ed to be hypermorphic in increasubstitutionchasesterol levels and appears in multiple mouse strains [ 17, 18].
(C ) Traces showing the GCaMP2 responses of a representative V1re9- (top) and a V1re12-tdTomato-expressing cell (bottom) to female and male urine samples from multiple mouse strains.
Indeed, phenotypes measured in multiple mouse strains can be used in GWA scans (genetic mapping studies similar to GWA studies in humans) to identify disease-causing genetic variants.
CIA is not inducible with peptides derived from CII, which differentiates it from EAE in which short peptides derived from multiple myelin antigens induce disease in multiple mouse strains.
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