Sentence examples for multiple miRNAs indicating from inspiring English sources
Notably, many transcripts (i.e., BCL6, PTEN, BNIP3L, PDCD4, NKX3-1, and GPNMB) are targeted by multiple miRNAs, indicating a pleiotropic effect in gene regulation by coexpressed endogenous miRNAs in MMG.
Noteworthy, single miRNAs can regulate the expression of hundreds of protein coding target mRNAs and, conversely, the expression of a single gene can be regulated by multiple miRNAs, indicating the complexity of miRNA-mRNA interrelationship and the great regulatory potential of miRNAs [ 13, 21, 22].
In addition, the ESCC miRNAs oppose the G1 arrest induced by these miRNAs, indicating ESCC miRNAs maintain the unique ESC cell cycle structure at multiple conditions.
When both let-7 and miR-30 were expressed in breast cancer, a much more significant inhibition of self-renewal of breast CSCs was observed compared to expression of either miRNA alone [112], indicating multiple miRNAs could be used to eliminate CSCs in anti-cancer therapy.
miR-588 but not miR-615-5p alsuppressedsed hPGRN expression in stable cell lines (data not shown), indicating that multiple miRNAs may be potential targets for therapeutic manipulation of hPGRN levels.
One target of Can_miR_06 is the growth-regulating factor gene (Os04g51190), which is also targeted by miR396 [ 35], indicating that multiple miRNAs may regulate the same gene family.
Recent studies indicate that multiple miRNAs have altered expression in HR-HPV containing CC cells as compared with HPV-negative CC cells or normal cervical tissues [ 30, 89].
A number of the miRNAs have multiple targets, indicating the diversity of these miRNAs.
This indicates the presence of multiple miRNAs broadly conserved in insects that have been lost in Drosophila.
Most of miRNA targeted multiple sites, indicating that a single miRNA can regulate more than one unigene.
These results indicated that the target prediction combined with pathway enrichment analysis is an effective approach in investigating the influence of multiple miRNAs.
