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Moreover, assessment of multiple miRNA expression levels can accurately predict prognosis and survival in lung cancer [ 21].
Gonadotropin-releasing hormone regulates multiple miRNA expression in gonadotrope cell lines, producing downregulation of miR-99b and miR-125b, and upregulation of miR-132, miR-151, miR-212, miR-222, miR-350, and miR-424 (Godoy et al. 2011).
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By targeting a gene with multiple miRNAs the expression of the gene can be subtly and precisely regulated.
Dap is predicted to be regulated by multiple miRNAs and expression of a Dap transgene lacking these putative miRNA-binding sites mimicked the phenotype of dcr-1 loss-of-function.
Since the target of a single miRNA may be multiple, dysregulation of miRNA expression may profoundly influence cancer-related signaling pathways [ 13].
Although multiple factors regulate miRNA expression in plants (Xie et al. 2010), one possible factor is differential accumulation of TEs, a feature that characterizes the two cotton genomes studied here (Hawkins et al. 2006).
Multiple regression of miRNA expression onto the relative cell-type frequencies for each group g. y g = β 0 + β 1 g x 1 g + ⋯ + β kg x kg + ε g = X β + ε, β0 g = 0; implies that at zero cell-type frequency there is zero miRNA expression.
Nicotine selectively modulates expression of multiple miRNAs and increases expression of miR-140, coordinated with the nicotine-augmented expression of its host gene WWP2.
It has been shown that classification of multiple cancers based on miRNA expression signatures is more accurate than mRNA based signatures [6].
The Kruskal-Wallis rank test followed by a Dunn's Multiple Correction test was used to determine the statistical significance of miRNA expression between multiple (>2) subgroups.
MiRNA expression affecting multiple genes simultaneously, provided support for this hypothesis.
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