Sentence examples similar to multiple metastatic pathways from inspiring English sources

In this review, we will summarize the role of deubiquitination and highlight the recent discoveries of DUBs with regards to multiple metastatic events including anti-apoptosis pathway and EMT.

Many oncogenic client proteins involved in formation of metastatic pathways.

Fig. 4 Multiple metastatic gastric polyps.

Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type are well described in the literature.

bPatients could have had multiple metastatic locations.

We assumed that the known metastatic pathways of primary cancers also apply to the metastatic spreading of CUP.

Single metastatic lesion in isolated location (organ or site) was reported to associate with prolonged survival versus multiple metastatic lesions in isolated or multiple locations [ 14– 16].

Among polymorphisms associated with protein-coding tumor suppressors and oncogenes, MET is a crucial gene to multiple oncogenic pathways and metastatic behavior.

Multiple cellular pathways influence the growth and metastatic potential of CRC.

Additional targets of let-7 have been proposed, including the high-mobility group AT-hook 2 HMGA2 Oncogene and collagen type I alpha 2, indicating that let-7 may act as a tumor suppressor by suppressing multiple oncogenic signaling pathways and metastatic factors [65], [76], [77].

The main reason for the poor prognosis observed in HCC patients is the highly proliferative and metastatic activities of HCC cells, which are the result of the deregulation of multiple signaling pathways [ 10].