Data demonstrate high metastases in case of PC3-Neo mice as evident from the presence of multiple metastatic nodules in lungs and livers.
The 13 mice included in the control group had multiple metastatic tumors in the lung, and the proportional area of pulmonary metastasis was 40±6%6%.
Taking the advantage of red fluorescent signaling, multiple metastatic foci in liver, lung as well as lymph nodes of posterior peritoneum were easy to be visualized in nude mice as early as 2 weeks after orthotopic transplantation.
Following a baseline staging CT, which confirmed multiple metastatic sites, including the lungs and adrenal gland, as well as a chronically collapsed left lung (first seen on CT prior to commencing erlotinib), he was commenced on crizotinib therapy 250 mg orally twice-daily.
In our study, we wanted to discriminate and analyse the characteristic of multiple synchronous lung cancers and metastatic lung cancers that without relying on collection of normal tissure.
Hematoxylin and eosin (H&E) staining of the lung tissue showed multiple metastatic sites in several xenografted MCF7-CT45A1 mice, with the absence of any lung metastasis in all of the MCF7-V-xenografted mice.
The CR occurred in a 21-year-old female with multiple metastatic lesions (3 in the lungs) who received a total of 9 cycles.
At the time of progression, 6 patients presented with a single metastatic site (all lung) and 3 with multiple metastatic sites (lung/liver, lung/bone, and lung/liver/bone) (Table 1).
Cisplatin was encapsulated in lipid vesicles that are dispersed throughout the aqueous phase and delivered via nebuliser to patients with advanced and/or metastatic lung cancer who had progressed after multiple other therapies (Wittgen et al, 2007).
Only five of the 19 responses were obtained in patients with multiple metastatic sites, the rest being liver only (11 patients), lung only (one patient) and extra hepatic intra-abdominal disease (two patients).
